The Exchangeability of Amino Acids in Proteins

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The exchangeability of amino acids in proteins.

The comparative analysis of protein sequences depends crucially on measures of amino acid similarity or distance. Many such measures exist, yet it is not known how well these measures reflect the operational exchangeability of amino acids in proteins, since most are derived by methods that confound a variety of effects, including effects of mutation. In pursuit of a pure measure of exchangeabil...

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ژورنال

عنوان ژورنال: Genetics

سال: 2005

ISSN: 1943-2631

DOI: 10.1534/genetics.104.039107